Undifferentiated carcinoma with osteoclast-like giant cells – a case report

Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells is an exceptionally rare malignancy, fewer than 100 cases reported to date. While histological features this entity have been well described, cytological diagnosis can present a challenge. This case report describes fine needle aspirate from heterogenous pancreatic mass in 75-year-old man. The smears revealed singularly dispersed and clustered marked atypia background histiocytes multinucleated cells. Immunohistochemistry performed on cell block showed weak immunoreactivity amongst atypical for CK8/18 absent staining CK7 SOX10. Both stained positive CD68. Overall, morphological immunohistochemical were suggestive undifferentiated These tumours are important recognise as absence conventional ductal adenocarcinoma they may more favourable prognosis.1 Reference 1. Muraki T, Reid MD, Basturk O, et al. osteoclastic pancreas: clinicopathologic analysis 38 highlights protracted clinical course currently appreciated. Am J Surg Pathol 2016; 40: 1203–16.